A practical vertical takeoff and acceleration strategy is developed for manned electric vertical takeoff and landing vehicles, with a simple vehicle operation principle defined. Firstly, a 6-DOF model is established for 120 kg reduced-scale protype electric vertical takeoff and landing vehicles, with its physical control principles illustrated. Then, a simple vehicle operation method is defined for the vehicle, where the conventional operation method for fixed-wings and helicopters is considered for a friendly stick response definition for pilots with different backgrounds. The defined simple vehicle operation principles are realized by a control architecture with a linear-active-disturbance-rejection-control-based inner loop stability augmentation system and an airspeed-based mode selection outer loop. This system is then used to perform a four-stage vertical takeoff and acceleration strategy, which targets at a smooth and safe transition. The Monte Carlo simulation results and the strategy simulations prove that the proposed strategy, which achieves the design target perfectly, can be easily performed with the developed simple vehicle operation system, and that it has sufficient robustness performance to reject at least 20% of the model’s uncertainties.