In this paper, we deal with the general fractional integrals and the general fractional derivatives of arbitrary order with the kernels from a class of functions that have an integrable singularity of power function type at the origin. In particular, we introduce the sequential fractional derivatives of this type and derive an explicit formula for their projector operator. The main contribution of this paper is a construction of an operational calculus of Mikusiński type for the general fractional derivatives of arbitrary order. In particular, we present a representation of the m-fold sequential general fractional derivatives of arbitrary order as algebraic operations in the field of convolution quotients and derive some important operational relations.