(R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile

descriptionPublicationkeyboard_double_arrow_right Article 26 Aug 2014 Germany English Publisher:MDPI AGJournal:Molbank, volume 2,014, page M834 (eissn: 1422-8599,

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Authors: Frings, Marcus; Atodiresei, Iuliana Luisa; Bolm, Carsten;

doi: 10.3390/m834 , 10.18154/rwth-conv-090617

(R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile

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Abstract

Copper-catalyzed cross-coupling between (S)-S-methyl-S-phenylsulfoximine (1) and 2-iodobenzonitrile (2) resulted in the discovery of an unprecedented one-pot triple arylation sequence to give (R)-(−)-2-[(5-oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin- 12-yl)amino]benzonitrile (4). Here, we describe the synthesis of the title compound (R)-4 and the elucidation of its structure by means of various techniques.

Country

Germany

Related Organizations

RWTH Aachen University
Germany
RWTH Aachen University (Medical Faculty)
Germany

Keywords

copper catalysis, sulfoximines, benzothiazines, arylation, Inorganic chemistry, QD146-197

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