Recent studies have greatly furthered our understanding of the Southern Bantu languages, but questions about the internal relationships of the Southern Bantu language subgroups and the validity of the clade as a whole still remain. This study attempts to reconstruct the consonant inventory of one proposed genetic clade, that of Tsonga-Copi (S50–S60). Using published dictionaries and reference works for each language of the subgrouping, a corpus of cognate vocabulary was assembled. Each term was then matched, where possible, to a reconstruction in the Bantu Lexical Reconstructions 3 (BLR3) database. Sound correspondences were identified and used to reconstruct the consonant inventory of Proto-Tsonga-Copi. In addition to the discovery of several typologically unusual sound changes, the results of this study also lend support to existing and developing hypotheses about both the internal relationships of Southern Bantu clades, as well as the nature of language contact in (pre)historic Southern Africa, particularly the influence of Khoisan and other Bantu languages.