Most maritime accidents are caused by human errors or failures. Providing early warning and decision support to the officer on watch (OOW) is one of the primary issues to reduce such errors and failures. In this paper, a quantitative real-time multi-ship collision risk analysis and collision avoidance decision-making model is proposed. Firstly, a multi-ship real-time collision risk analysis system was established under the overall requirements of the International Code for Collision Avoidance at Sea (COLREGs) and good seamanship, based on five collision risk influencing factors. Then, the fuzzy logic method is used to calculate the collision risk and analyze these elements in real time. Finally, decisions on changing course or changing speed are made to avoid collision. The results of collision avoidance decisions made at different collision risk thresholds are compared in a series of simulations. The results reflect that the multi-ship collision avoidance decision problem can be well-resolved using the proposed multi-ship collision risk evaluation method. In particular, the model can also make correct decisions when the collision risk thresholds of ships in the same scenario are different. The model can provide a good collision risk warning and decision support for the OOW in real-time mode.