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The Dark Side of Cell Fusion

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 28 Apr 2016 Switzerland Publisher:MDPI AGJournal:International Journal of Molecular Sciences, volume 17, page 638 (eissn: 1422-0067,

Authors: Bastida Ruiz, Daniel; Van Hoesen, Kylie; Cohen, Marie-Benoîte;

doi: 10.3390/ijms17050638

pmid: 27136533

pmc: PMC4881464

The Dark Side of Cell Fusion

- Summary
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Abstract

Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.

Country

Switzerland

Related Organizations

University of Geneva
Switzerland

Keywords

Gene Products, env, Bone Marrow Cells, Review, Pregnancy Proteins, Neoplastic Cells, Circulating, Models, Biological, Trophoblasts, 618, Cell Fusion, Neoplastic Stem Cells, Humans, Neoplasm Metastasis, ddc: ddc:618

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	78
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%