Climate change restricts and alters the distribution range of plant species. Predicting potential distribution and population dynamics is crucial to understanding species’ geographical distribution characteristics to harness their economic and ecological benefits. This study uses Dendrocalamus brandisii as the research subject, aiming to accurately reveal the impact of climate change on this plant. The findings offer important insights for developing practical conservation and utilization strategies, and guidance for future introduction and cultivation. The MaxEnt model was optimized using regularization multiplier (RM) and feature combination (FC) from the ‘Kuenm’ package in R language, coupled with ArcGIS for modeling 142 distribution points and 29 environmental factors of D. brandisii. This article explored the key environmental factors influencing the potential suitable regions for D. brandisii, and predicted trends in habitat changes under SSPs2.6 and SSPs8.5 climate scenarios for the current era, the 2050s, 2070s, and 2090s. (1) The results show that when FC = QPH and RM = 1, the AUC = 0.989, indicating that the model prediction is accurate with the lowest complexity and overfitting. The key environmental factors affecting its primary suitable distribution, determined by jackknife training gain and single-factor response curve, are the precipitation of warmest quarter (bio18), the temperature seasonality (bio4), the minimum average monthly radiation (uvb-4), and elevation (Elev), contributing 93.6% collectively. It was established that the optimal range for D. brandisii is precipitation of warmest quarter of between 657 and 999 mm, temperature seasonality from 351% to 442%, minimum average monthly radiation from 2420 to 2786 J/m2/day, at elevation from 1099 to 2217 m. (2) The current potential habitat distribution is somewhat fragmented, covering an area of 92.17 × 104 km2, mainly located in southwest, south, and southeast China, central Nepal, southern Bhutan, eastern India, northwestern Myanmar, northern Laos, and northern Vietnam. (3) In future periods, under different climate scenario models, the potential habitat of D. brandisii will change in varying degrees to become more fragmented, with its distribution center generally shifting westward. The SSP8.5 scenario is not as favorable for the growth of D. brandisii as the SSPs2.6. Central Nepal, southern Bhutan, and the southeastern coastal areas of China have the potential to become another significant cultivation region for D. brandisii. The results provide a scientific basis for the planning of priority planting locations for potential introduction of D. brandisii in consideration of its cultivation ranges.