Intellectual humility (IH), defined as the extent to which one is aware of one’s own intellectual limitations, is an understudied construct in organizational research. As a moral virtue, IH has been studied in philosophy and religion for decades. As a psychological and behavioral tendency construct, IH has gained significant attention among psychology researchers over the past decade due to rising extremism regarding social and political issues in the US and around the world. One reason for the increased research interest in IH includes the potential benefits from IH in terms of reducing social and political polarization and reducing stress and anxiety, which may improve individual overall well-being. This article provides an overview of IH as a multi-dimensional construct, its psychometric properties and nomological network, and its potential benefits in organizations and employee well-being. The article concludes with a call for more interdisciplinary research on improving our knowledge and theories of IH as well as its construct measurement considering the recent coming-of-age adoption of artificial intelligence (AI) models to harness the power of IH in sustaining individual well-being.