This survey highlights the significant role of exponential operators and the monomiality principle in the theory of special polynomials. Using operational calculus formalism, we revisited classical and current results corresponding to a broad class of special polynomials. For instance, we explore the 2D Hermite polynomials and their generalizations. We also present an integral representation of Gegenbauer polynomials in terms of Gould–Hopper polynomials, establishing connections with a simple case of Gegenbauer–Sobolev orthogonality. The monomiality principle is examined, emphasizing its utility in simplifying the algebraic and differential properties of several special polynomial families. This principle provides a powerful tool for deriving properties and applications of such polynomials. Additionally, we review advancements over the past 25 years, showcasing the evolution and extensive applicability of this operational formalism in understanding and manipulating special polynomial families.