In C-V2X (cellular vehicle-to-everything) communication networks, dense spatial reuse of the available radio spectrum is required to achieve efficient spectral usage. Spectrum reuse causes severe network interference where signals from many undesired transmitters are aggregated at a receiver. This paper investigates the 3D spatial characteristics of C-V2X communication interference in the angular domain. A 3D GIDM (Gaussian interference distribution model) is proposed, and the corresponding interference APD (angular power density) is given. Then, the closed-form expressions of some key spatial statistics of interference are derived based on the interference APD. Finally, the closed-form expressions of the probability density function and spatial correlation function of SIR (signal–to–interference ratio) are derived based on the 3D multipath APD model and spatial statistics of the Rice channel. Simulation analysis shows that 3D spatial angular directions have significant effect on these spatial statistics of interference and the spatial correlation function of SIR. The results provide useful insight on the analysis and design of the interference-limited networks.