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Arginine and Endothelial Function

Authors: Gambardella, Jessica; Khondkar, Wafiq; Morelli, Marco Bruno; Wang, Xujun; Santulli, Gaetano; Trimarco, Valentina;

Arginine and Endothelial Function

Abstract

Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

Country
Italy
Keywords

hypertension, endothelium, QH301-705.5, L-arginine, heart failure, arginine, Review, peripheral artery disease, endothelial dysfunction, arginine paradox, dietary supplements, nitric oxide, eNOS uncoupling, NADPH, oxidative stress, Biology (General), ADMA; BH4; COVID-19; L-arginine; NADPH; arginine; arginine paradox; blood pressure; dietary supplements; eNOS uncoupling; endothelial dysfunction; endothelium; heart failure; hypertension; myocardial infarction; nitric oxide; oxidative stress; peripheral artery disease, BH4, blood pressure, COVID-19, ADMA, myocardial infarction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    181
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
181
Top 1%
Top 10%
Top 0.1%
Green
gold