This paper explores the operational principles and monomiality principles that significantly shape the development of various special polynomial families. We argue that applying the monomiality principle yields novel results while remaining consistent with established findings. The primary focus of this study is the introduction of degenerate multidimensional Hermite-based Appell polynomials (DMHAP), denoted as An[r]H(l1,l2,l3,…,lr;ϑ). These DMHAP forms essential families of orthogonal polynomials, demonstrating strong connections with classical Hermite and Appell polynomials. Additionally, we derive symmetric identities and examine the fundamental properties of these polynomials. Finally, we establish an operational framework to investigate and develop these polynomials further.