This work focuses on solving and analyzing two-point fuzzy boundary value problems in the form of fractional ordinary differential equations (FFOBVPs) using a new version of the approximation analytical approach. FFOBVPs are useful in describing complex scientific phenomena that include heritable characteristics and uncertainty, and obtaining exact or close analytical solutions for these equations can be challenging, especially in the case of nonlinear problems. To address these difficulties, the optimal homotopy asymptotic method (OHAM) was studied and extended in a new form to solve FFOBVPs. The OHAM is known for its ability to solve both linear and nonlinear fractional models and provides a straightforward methodology that uses multiple convergence control parameters to optimally manage the convergence of approximate series solutions. The new form of the OHAM presented in this work incorporates the concepts of fuzzy sets theory and some fractional calculus principles to include fuzzy analysis in the method. The steps of fuzzification and defuzzification are used to transform the fuzzy problem into a crisp problem that can be solved using the OHAM. The method is demonstrated by solving and analyzing linear and nonlinear FFOBVPs at different values of fractional derivatives. The results obtained using the new form of the fuzzy OHAM are analyzed and compared to those found in the literature to demonstrate the method’s efficiency and high accuracy in the fuzzy domain. Overall, this work presents a feasible and efficient approach for solving FFOBVPs using a new form of the OHAM with fuzzy analysis.