Steering has more potential than braking to prevent rear-end collisions at higher relative velocities. A path tracking controller based on multi-input multi-output (MIMO) model predictive control (MPC) is proposed to enhance the handling performance of autonomous emergency steering in this paper. A six-state MIMO bicycle model including actuator dynamics of steering and differential braking is used for model prediction. Two control inputs are front wheel steering angle and direct yaw moment. Two model outputs are lateral displacement and heading angle. According to the work load ratios at four wheels, control allocation is used to determine the optimal braking force distribution to prevent tire force saturation. The performance of a single-input single-output (SISO) MPC that uses only steering angle control to track the lateral displacement of the desired path is employed to benchmark the performance of the proposed algorithm. Simulation results show that both SISO MPC and MIMO MPC can track the path on nominal road surface with high road friction coefficient of 0.9. For a road surface with medium road friction coefficient of 0.7, the SISO MPC is unable to track the path and loses directional stability. However, the MIMO MPC can still track the path and demonstrate robust path tracking and handling enhancement against model uncertainty due to reduced road friction.