Improper herbicide application without proper personnel protection (PPE) can be harmful. Herbicide application with microsprinkler irrigation reduces direct contact with herbicides with the benefits of being highly efficient, decreasing water and herbicide use, and using precise irrigation and concentration control during agricultural production. Therefore, to propose a reasonable strategy for applying microsprinkler irrigation, a laboratory test was conducted to study the water distribution characteristics, and different herbicide concentrations (1.5 g/L, 2.0 g/L, and 3.0 g/L) were used in a field irrigation experiment with polyethylene microsprinkler hoses. Wheat was selected as the test crop, and the effects of the different herbicide concentrations were compared and analyzed based on the weed control effect and weed control uniformity. The results showed that in comparison to other herbicide concentrations, a higher herbicide application concentration (3.0 g/L) did not have a better application effect. Application concentration and duration influenced each other and synergistically affected the application effect. The weed control effects of the herbicide concentrations at 1.5 g/L and 2.0 g/L were similar and had better application effects than those of the other concentrations. When using this approach, the specific herbicide concentration should be determined according to the crop and soil environmental conditions, and the application concentration and duration should be adjusted reasonably.