Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
Copyright policy )Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.
- Children's Cancer Institute Australia Australia
- UNSW Sydney Australia
Physiology, pancreatic cancer, hypoxia., 610, 32 Biomedical and Clinical Sciences, Stroma, pancreatic stellate cells, anzsrc-for: 0606 Physiology, anzsrc-for: 1116 Medical Physiology, Pancreatic Cancer, Rare Diseases, anzsrc-for: 32 Biomedical and Clinical Sciences, anzsrc-for: 3208 Medical physiology, stroma, 2.1 Biological and endogenous factors, QP1-981, Cancer, anzsrc-for: 3204 Immunology, anzsrc-for: 3211 Oncology and Carcinogenesis, hypoxia, fibrosis, Pancreatic Stellate Cells, chemoresistance, anzsrc-for: 1701 Psychology, anzsrc-for: 3101 Biochemistry and cell biology, 3211 Oncology and Carcinogenesis, Fibrosis, 3204 Immunology, Orphan Drug, Digestive Diseases
Physiology, pancreatic cancer, hypoxia., 610, 32 Biomedical and Clinical Sciences, Stroma, pancreatic stellate cells, anzsrc-for: 0606 Physiology, anzsrc-for: 1116 Medical Physiology, Pancreatic Cancer, Rare Diseases, anzsrc-for: 32 Biomedical and Clinical Sciences, anzsrc-for: 3208 Medical physiology, stroma, 2.1 Biological and endogenous factors, QP1-981, Cancer, anzsrc-for: 3204 Immunology, anzsrc-for: 3211 Oncology and Carcinogenesis, hypoxia, fibrosis, Pancreatic Stellate Cells, chemoresistance, anzsrc-for: 1701 Psychology, anzsrc-for: 3101 Biochemistry and cell biology, 3211 Oncology and Carcinogenesis, Fibrosis, 3204 Immunology, Orphan Drug, Digestive Diseases
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