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Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 30 Nov 2021 United Kingdom, Australia Publisher:Frontiers Media SAJournal:Frontiers in Cell and Developmental Biology, volume 9 (eissn: 2296-634X, Copyright policy )
Authors: Zi Lv; Zi Lv; Zi Lv; Li-ling Xiong; Li-ling Xiong; Li-ling Xiong; Xian Qin; +15 Authors

doi: 10.3389/fcell.2021.694261

pmid: 34917606

pmc: PMC8670385

handle: 11343/305259

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis

Abstract

Graphical AbstractLv et al. show that trophoblastic GRK2 deficiency could promote placenta dysfunction and PE-like phenotype by activating necroptosis in trophoblasts, then inducing cytokine disturbance in circulation.

Countries
United Kingdom, Australia
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Keywords

618, preeclampsia, Cell and Developmental Biology, cell death, QH301-705.5, 610, GRK2, necroptosis, Biology (General), trophoblast

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 17
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Top 10%
Average
Top 10%
Green
gold