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Sparse bayesian learning for genomic selection in yeast

Authors: Maryam Ayat; Mike Domaratzki;

Sparse bayesian learning for genomic selection in yeast

Abstract

Genomic selection, which predicts phenotypes such as yield and drought resistance in crops from high-density markers positioned throughout the genome of the varieties, is moving towards machine learning techniques to make predictions on complex traits that are controlled by several genes. In this paper, we consider sparse Bayesian learning and ensemble learning as a technique for genomic selection and ranking markers based on their relevance to a trait. We define and explore two different forms of the sparse Bayesian learning for predicting phenotypes and identifying the most influential markers of a trait, respectively. We apply our methods on a Saccharomyces cerevisiae dataset, and analyse our results with respect to existing related works, trait heritability, as well as the accuracies obtained from linear and Gaussian kernel functions. We find that sparse Bayesian methods are not only competitive with other machine learning methods in predicting yeast growth in different environments, but are also capable of identifying the most important markers, including both positive and negative effects on the growth, from which biologists can get insight. This attribute can make our proposed ensemble of sparse Bayesian learners favourable in ranking markers based on their relevance to a trait.

Related Organizations
Keywords

machine learning, kernel learning, Bioinformatics, bayesian learning, Computer applications to medicine. Medical informatics, R858-859.7, marker assisted selection, genomic selection, relevance vector machine

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold