Abstract Two experiments were conducted with large-type, male turkeys to investigate ways in which the elimination of dieldrin in body tissues might be accelerated. In experiment 1, eleven-week old turkeys were given 0.30 p.p.m. dietary dieldrin for 5 days. After treatment, dieldrin concentration in body fat was 1.64 p.p.m. The turkeys were divided into five treatment groups and the rate of decline in tissue dieldrin was determined periodically during a 68-day period. Compared to a normal feeding program, the use of a ration high in fiber (33% ground alfalfa) or a ration high in energy and protein did not accelerate dieldrin depletion from body fat. Decline in tissue dieldrin was not changed by depriving the turkeys of feed for the first five days of the depletion period, followed by a normal feeding schedule. Sodium barbital, an inducer of mammalian hepatic enzymes, administered in the drinking water did not increase elimination of dieldrin from the turkeys. In experiment 2, twelve-week old turkeys were used. The turkeys were fed 0.29 p.p.m. dieldrin for five days, at which time the average dieldrin concentration in the adipose fat was 1.33 p.p.m. The turkeys were divided into two treatment groups. One group was fed a normal ration program for 61 days. The second group was subjected to three successive periods of fasting (7, 7 and 4 days, respectively) interrupted by periods of feeding (7, 12 and 24 days, respectively). Periodic fasting was effective in accelerating the decline in both the concentration of dieldrin in body fat and the total amount of dieldrin in the carcasses of the turkeys.