Age-Related Changes in Serum Guanidinoacetic Acid in Women

descriptionPublicationkeyboard_double_arrow_right Article 25 Oct 2019 English Publisher:Institute of Physiology of the Czech Academy of SciencesJournal:Physiological Research (issn: 0862-8408, eissn: 1802-9973,

Copyright policy )

Authors: A, Olah; V, Stajer; L, Ratgeber; J, Betlehem; S M, Ostojic;

doi: 10.33549/physiolres.934189

pmid: 31647299

Age-Related Changes in Serum Guanidinoacetic Acid in Women

- Summary
- Subjects
- Metrics

Abstract

Guanidinoacetic acid (GAA) is a fundamental intermediate in cellular bioenergetics, with circulating levels of GAA often reflects disturbances in its conversion due to many intrinsic and extrinsic factors, including gender or age. Here, we evaluated serum GAA in 172 healthy women aged 18 to 65 years, with age found to significantly predict serum GAA concentrations (r=0.29, P=0.03). This perhaps nominates serum GAA as a novel gender-specific proxy of impaired bioenergetics with aging.

Related Organizations

University of Pecs
Hungary
University of Novi Sad
Serbia

Keywords

Adult, Aging, Adolescent, Glycine, Middle Aged, Young Adult, Humans, Female, Independent Living, Energy Metabolism, Exercise, Biomarkers, Aged

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average