Adipose Tissue and Atherosclerosis

descriptionPublicationkeyboard_double_arrow_right Article 18 Nov 2015 English Publisher:Institute of Physiology of the Czech Academy of SciencesJournal:Physiological Research (issn: 0862-8408, eissn: 1802-9973,

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Authors: R, Poledne; I, Králová Lesná; S, Čejková;

doi: 10.33549/physiolres.933152

pmid: 26680673

Adipose Tissue and Atherosclerosis

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Abstract

High-energy intake which exceeds energy expenditure leads to the accumulation of triglycerides in adipose tissue, predominantly in large-size adipocytes. This metabolic shift, which drives the liver to produce atherogenic dyslipidemia, is well documented. In addition, an increasing amount of monocytes/macrophages, predominantly the proinflammatory M1-type, cumulates in ectopic adipose tissue. The mechanism of this process, the turnover of macrophages in adipose tissue and their direct atherogenic effects all remain to be analyzed.

Related Organizations

Institute of Clinical and Experimental Medicine
Czech Republic

Keywords

Macrophages, Atherosclerosis, Adipose Tissue, Adipocytes, Animals, Humans, Obesity, Insulin Resistance, Energy Metabolism

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