In the recent past, the world has witnessed massive progress and development in the field of science. So many factors like technological know-how, new inventions and discoveries, enhancement of health and hygiene, globalization, and others govern the current trend. Bediuzzaman Said Nursi expressed that the current period―dominated by the scientific developments―demands to weld religious knowledge and the one based on experiments―scientific knowledge―together. Said Nursi endeavored vehemently to revitalize the prevailing system of education and the proposal of the university―Madresatü’z Zehrā was a step toward the accomplishment of the aforementioned dream. Nursi’s own life as well as his writings (Risale-i-Nur) greatly contributed to the need and necessity of the integration of knowledge. In this context, the current study is a humble effort to present besides the concept of knowledge, an overview of Said Nursi’s attempts and approach towards the integration of religious and scientific knowledge for the prosperity and all-round development of humanity. The study also highlights that these efforts, meant to revitalize the concept of knowledge in a broader sense, were aimed to solve religion-science controversy or religion science compatibility.