Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?
Copyright policy )Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?
Abstract The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimer’s disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age- and gender-matched patients with mild cognitive impairment (MCI) due to AD ( n = 18), dementia due to AD ( n = 19), and age-matched cognitively healthy controls ( n = 14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.
- Vrije Universiteit Brussel Belgium
- University of Antwerp Belgium
- Ghent University Belgium
- Katholieke Universiteit Leuven Belgium
- ZNA Middelheim Hospital Belgium
Male, White Matter/pathology, Alzheimer Disease/cerebrospinal fluid, Magnetic Resonance Imaging/methods, Diagnosis, Differential, Cognitive Dysfunction/cerebrospinal fluid, Atlases as Topic, atrophy, Diffusion Tensor Imaging/methods, Alzheimer Disease, Image Interpretation, Computer-Assisted, Humans, Biomarkers/cerebrospinal fluid, Brain/pathology, Cognitive Dysfunction, Prospective Studies, Aged, Aged, 80 and over, Image Interpretation, Computer-Assisted/methods, Brain, Middle Aged, Magnetic Resonance Imaging, White Matter, Diffusion Tensor Imaging, Female, Atrophy, aged, 80 and over, Mental Status Schedule, Biomarkers, Research Article
Male, White Matter/pathology, Alzheimer Disease/cerebrospinal fluid, Magnetic Resonance Imaging/methods, Diagnosis, Differential, Cognitive Dysfunction/cerebrospinal fluid, Atlases as Topic, atrophy, Diffusion Tensor Imaging/methods, Alzheimer Disease, Image Interpretation, Computer-Assisted, Humans, Biomarkers/cerebrospinal fluid, Brain/pathology, Cognitive Dysfunction, Prospective Studies, Aged, Aged, 80 and over, Image Interpretation, Computer-Assisted/methods, Brain, Middle Aged, Magnetic Resonance Imaging, White Matter, Diffusion Tensor Imaging, Female, Atrophy, aged, 80 and over, Mental Status Schedule, Biomarkers, Research Article
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