Weed management in modern agriculture is crucial to avoid yield losses and ensure food security. Climate change, intensive agricultural practices, and natural disasters change weed dynamics, requiring changes in weed management strategies. In addition to labor shortages, manual and chemical control options are no longer viable because of weed resistance to herbicides and the effects of eco-degradation and health hazards. As a result, weed management strategies that boost agricultural productivity are urgently needed. Precision agriculture has become one alternative for managing weeds, using tools and technologies to boost farm productivity. Recent innovations in precision application technology have made it possible to make smaller treatment units that can be applied to meet sitespecific demands. These systems combine ground-based and aerial weed sensing systems (that are site-specific, need-specific, and cost-effective) with integrated weed management. Despite the viability of all of these strategies in today's agriculture, site-specific selections and the appropriate combination of these eco-friendly strategies can efficiently reduce herbicide use, and ensure environmental protection while enhancing weed control efficiency and crop yield.