Abstract Tomato spotted wilt virus (TSWV) resistant, runner-type peanut (Arachis hypogaea L.) cultivars are the most important defense to control spotted wilt disease in southeast U.S. peanut production. The objective of this 3-yr (1999–01) study was to evaluate six TSWV-resistant, runner-type cultivars (Southern Runner, Florida MDR 98, C-99R, ViruGard, Georgia Green, and Georgia-OIR) at three different seeding rates (3, 5, and 7 seed/30.5 cm) in single conventional row patterns for possible genotype (GE) × seeding rate (SR) interaction at the Univ. of Georgia, Coastal Plain Experiment Station. The combined split-plot analyses of variance resulted in highly significant (P ≤ 0.01) GE × SR interaction, which indicates that not all six runner-type cultivars performed the same at each of these three seeding rates. A good example was the TSWV-resistant, runner-type peanut cultivar Georgia Green. It performed subpar at the below normal or lowest seeding rate; whereas at the highest seeding rate, Georgia Green and Georgia-OIR produced the highest pod yields and dollar value returns per hectare among all of these runner-type cultivars. TSWV disease incidence was also significantly lower for the TSWV-resistant Georgia Green cultivar at each of the two higher seeding rates compared to the lowest seeding rate.