This study explores the multiple helices extended from the Triple Helix (TH) Model of innovation. Describing what Triple Helix, Quadruple Helix and Quintuple Helix Model as well as and Mode3 is the primary motive of this paper. This study is solely based on secondary sources and the research is exploratory as well as descriptive in its nature. Originally proposed by Henry Etzkowitz and Loet Leydesdorff (1995), the TH Model elucidated innovation dynamics stemming from interactions among academia, industry, and government. Building upon this foundation, the Quadruple Helix Model was introduced as the fourth helix, emphasizing basically on the role of civil society in innovation processes, thus highlighting aspects of social inclusion, public engagement, and ethical considerations. Likewise, the Quintuple Helix Model incorporates socio-ecological interactions, emphasizing the generation and dissemination of knowledge impacting the natural environment. This framework basically depicts opportunities for addressing new challenges such as climate change through innovation for sustainable development within the knowledge society and economy. Similarly, exploring the implications of Mode 1, Mode 2, and Mode 3 knowledge on economy, society and democracy, this study also attempts to investigate the evolution of innovation helix models and their impact on fostering inclusive, collaborative, and sustainable innovation ecosystems. In course of studying the model of innovation system, there come simple question about how the Triple Helix Model of innovation has been extended up to Quintuple Helix via Quadruple Helix Model of innovation. This is a policy-based research which will help to the stakeholders like academics, planners, researchers, industry leaders, entrepreneurs, and governing bodies for understanding Triple Helix, Quadruple Helix and Quintuple Helix model in better way.