This reflexive article combines recent as well as established insights from various anthropological subfields and beyond to address a world that is increasingly on the move, and this in ways that we do not fully understand, let alone manage or control. As such, the text involves a critical thinking exercise that focuses on the importance of processes of motion and communication, ranging from planetary and even cosmic mobilities to micro-movements and exchanges at the cellular and atomic levels. Taking this broader context of mobility and change into account in the Anthropocene Epoch automatically leads to a serious overhaul of how “the human” has traditionally been understood and the vital role of what we have come to term “the environment”. This radical rethinking has obvious consequences for a human-centered scientific discipline like anthropology in terms of ontologies and epistemologies, theories and methodologies. I end the article by offering some concrete suggestions on how anthropology, as a holistic discipline without clear-cut boundaries, can position itself in a world that is currently undergoing very rapid changes.