Structural priming, the tendency for speakers to reuse previously encountered sentence structures, provides some of the strongest evidence for the existence of abstract structural representations in language. In the present research, we investigate the priming of semantic structure in Brazilian Portuguese using the locative alternation: A menina lustrou a mesa com o verniz “The girl rubbed the table with the polish” vs. A menina lustrou o verniz na mesa “The girl rubbed the polish on the table.” On the surface, both locative variants have the same syntactic structure: NP-V-NP-PP. However, location-theme locatives (“rub table with polish” describe a caused-change-of-state event, while theme-location locatives (“rub polish on table”) describe a caused-change-of-location event. We find robust priming on the basis of these semantic differences. This work extends our knowledge by demonstrating that semantic structural priming is not isolated to languages like English (e.g., satellite-framed with strict word order and limited inflection) but is present in a language with very different typological characteristics (e.g., verb-framed and richly inflected with subject dropping).