A simple, inexpensive, and efficient one-pot synthesis of 1,4-dihydropyridine via Hantzsch reaction was achieved in good to excellent yields under catalyst free conditions by using PEG400 as solvent. In this reaction, PEG-400 was used as the solvent, which has such advantages: absolutely nontoxic, inexpensive, thermally stable, recoverable and easy to dispose in the reaction. And the corresponding products: 1,4-Dihydropyridine derivatives are very important in organic chemistry and medicine industry, by the using of PEG, the yields of the reaction were all very high(most above 95%). Finally, as to the inexpensive of PEG-400 and the high yields of the reaction, also because of the easy-treated procedures, this kind of reaction could be easier to produce in industrial. So, Polyethylene glycol offers a convenient, inexpensive, non-ionic liquid, non-toxic and recyclable reactions . Keywords-1,4-Dihydropyridines, Hantzsch reaction, Multicomponent synthesis, PEG400, Catalyst free.