Abstract The use of calcium D‐pantothenate in feed and water for drinking and of D‐panthenol in water for drinking is safe for all animal species and categories. The use of calcium D‐pantothenate and D‐panthenol as nutritional additives does not give rise to concern for consumers. Data from an acute inhalation toxicity study allowed to consider the substance of low toxicity by inhalation. D‐panthenol being currently only available in liquid preparations, the FEEDAP Panel does not anticipate any inhalation hazard. Calcium D‐pantothenate is not regarded as an irritant to skin and eyes; because of the lack of data it is considered as a skin sensitiser. D‐Panthenol is regarded as a skin and eye irritant; D‐panthenol was not a skin sensitiser in guinea pigs, however allergic rashes in humans have been reported following its topical use. A risk for the environment resulting from the use of pantothenic acid in animal nutrition is not foreseen. Due to its established nutritional role in domestic animals, calcium D‐pantothenate is regarded as an effective source of pantothenic acid. D‐Panthenol is considered a pro‐vitamin essentially bioequivalent to pantothenic acid.