Multifunctional biological products based on strains of microorganisms that are antagonists of pathogens and plant disease resistance activators - chitosan and its derivatives increase the content of chlorophyll α and b in flag leaves of wheat, the number and weight of grains in the ear, potential yield, and also reduce the development of yellow rust. The maximum biological effectiveness for these indicators was noted in the experimental version, where Bacillus subtilis VKM B-2604D and B. subtilis VKM B-2605D strains that are part of the Vitaplan biological product and chitosan salicylate (Chitosan II) complex was used.