Aim/Purpose: The Informing Science Institute (ISI) is an informing system, designed using informing science principles, for the express purpose of informing researchers who study problems related to informing. This paper describes the ISI as an applied instance of an informing system and analyzes the channels, informers, and clients of the ISI. Background: This paper begins with a brief overview of the current activity of the ISI, as well as an introduction to informing science philosophy and an explanation of the need for a transdiscipline. The ISI is a non-profit organization that provides several informing channels, including 13 open-access, peer-reviewed journals, as well as conferences, books, and outreach activities. Methodology: Statistical analyses of the authors, institutions, and countries of origin were conducted for every ISI paper published between 1998 and December of 2019. Additionally, interviews were conducted with 5 current and former Editors-in-Chief of ISI journals. Contribution: This paper provides a current description and analysis of the ISI informing system’s channels, informers, and clients. Findings: The ISI has published over 4,100 articles by over 4,500 authors from over 600 universities. Statistical analyses of articles published in ISI journals demonstrated that the ISI is characterized in part by robust international participation, with significant participation by authors from countries that have been traditionally under-represented in academic publications. The ISI achieved these outcomes through the use of the philosophical principles and design guidelines for informing science.