Regulation of transcription in cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:IMR PressJournal:Frontiers in Bioscience, volume 17, page 316 (issn: 1093-9946, eissn: 1093-4715,

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Authors: Elzbieta, Trzyna; Marcin, Duleba; Marta, Faryna; Marcin, Majka;

doi: 10.2741/3929

pmid: 22201746

Regulation of transcription in cancer

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Abstract

The purpose of this article is to provide an overview on the regulation of transcription in cancer cells. We describe here standard mechanisms of transcription in eukaryotic cells, an influence of common promoter polymorphisms contributing to malignant progression and DNA methylation as significant aspect of gene regulation. We also described transcription factors mechanism of action, and how their alteration can result in cancer.

Related Organizations

Jagiellonian University
Poland

Keywords

Gene Expression Regulation, Neoplastic, Polymorphism, Genetic, Transcription, Genetic, Neoplasms, Disease Progression, Humans, DNA Methylation, Proto-Oncogene Proteins c-met, Promoter Regions, Genetic

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