Role of RNA structure and protein factors in the control of HIV-1 splicing
Copyright policy )Role of RNA structure and protein factors in the control of HIV-1 splicing
Alternative splicing plays a key role in the production of numerous proteins by complex lentiviruses such as HIV-1. The study of HIV-1 RNA splicing has provided useful information not only about the physiology of the virus, but also about the general mechanisms that regulate mammalian pre-mRNA alternative splicing. Like all retroviruses, a fraction of HIV-1 transcripts remains intact to serve as genomic RNA and to code for Gag and Gag-Pol protein precursors. In addition, splicing is important for controlling the production of some viral proteins, which could otherwise have a negative effect on the infected cell. Here, we summarize how the utilization of HIV-1 splicing sites is limited by the binding of nuclear factors to cis-acting silencer elements, taking into account the role of RNA secondary structure in these mechanisms. We also describe how the poorly efficient HIV-1 acceptor sites are nevertheless activated by serine/arginine-rich proteins. Finally, we discuss how nuclear factors that interact with both the transcription and splicing machineries also participate in the control of HIV-1 RNA splicing.
- French National Centre for Scientific Research France
- Grenoble Alpes University France
- University of Lorraine France
- University of Strasbourg France
- UNIVERSITE DE NANCY II France
[SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, 570, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Regulatory Sequences, Nucleic Acid, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Viral Proteins, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 616, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, Molecular Biology/Genomics [q-bio.GN], [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Molecular Biology/Molecular Networks [q-bio.MN], [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], Exons, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Molecular Biology/Molecular biology, Alternative Splicing, [SPI.AUTO] Engineering Sciences [physics]/Automatic, [SDV.BBM.MN] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, HIV-1, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Nucleic Acid Conformation, RNA, Viral, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
[SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, 570, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Regulatory Sequences, Nucleic Acid, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Viral Proteins, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 616, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, Molecular Biology/Genomics [q-bio.GN], [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Molecular Biology/Molecular Networks [q-bio.MN], [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], Exons, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Molecular Biology/Molecular biology, Alternative Splicing, [SPI.AUTO] Engineering Sciences [physics]/Automatic, [SDV.BBM.MN] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, HIV-1, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Nucleic Acid Conformation, RNA, Viral, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
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