A systems study is underway of astronaut missions to Mars that could be accomplished over the next four decades. In addition to an emphasis on the transportation and facility infrastructure required for such missions, other relevant technologies and mission constraints are also being considered. These induce on-orbit assembly, trajectory type, launch opportunities, propellant storage, crew size, cabin pressure, artificial gravity, life-support systems, radiation hazards, power/energy storage, thermal control, human factors, communications, abort scenarios, landing techniques, exploration strategies, and science activities. A major objective of the study is to identify enabling and significantly enhancing technologies for accomplishing the goal of the human exploration of Mars.