Two efficient design configurations of a liquid desiccant cooling/dehumidification system that can be powered by low grade solar or geothermal energy and promise low parasitic power requirements for blowers and pumps are proposed and analyzed in this work. A mathematical model for each component in this system has been developed and synthesized for system simulation. The system performance is predicted and optimized through parametric studies using the computer code LIQSYS. It is shown that the exhaust recirculation mode (ERM) gives better performance at full capacity while the process recirculation mode (PRM) produces cooler and drier air.