An analysis of roughness-induced boundary-layer transition examines the sensitivity of the Orbiter boundary-layer transition criteria to surface cooling, to surface roughness, and to the assumed flow-field model. The experimental data were obtained using a 0.0175-scale Orbiter with surface roughness represented by misaligned heat-shield tiles for surface temperatures from 0.12 stagnation temperature (a value typical of entry conditions) to 0.42 stagnation temperature (a value typical of continuous-flow wind-tunnels). Tile misalignment had only a slight effect on the heat transfer and on the trasition locations for wall temperature = 0.42 stagnation temperature. Cooling the boundary layer caused the tile-induced disturbances to increase significantly, promoting premature transition. Correlation of the effects of the misalignment height and of surface cooling in promoting transition are presented and predictions are made for typical Orbiter entry conditions.