We provide a detailed description of the structures along a 300 km long and 50 km wide transect across the Central Asian Orogenic Belt (CAOB) in southwestern Mongolia, covering the Precambrian Dzabkhan continental domain with overthrust Neoproterozoic ophiolites in the north (Lake Zone), a Silurian-Devonian passive margin association (Gobi-Altai Zone) and oceanic domain (Trans-Altai Zone) in the center, and a continental area (South Gobi Zone) in the south. Structural analysis suggests late Cambrian collapse of the thickened Lake Zone continental crust, leading to stretching of the lithosphere and followed by Silurian-Devonian formation of oceanic crust in the Trans-Altai domain. Subsequent emplacement of Devonian-Carboniferous and late Carboniferous magmatic arcs occurred on the Gobi-Altai and South Gobi Zone crusts, respectively, during E-W shortening. Finally, the entire system was affected by N-S convergence from the Permian to Jurassic, leading to heterogeneous shortening of the orogenic domain. The model best fitting these observations is one of generalized westward drift of the Tuva-Mongol-Dzabkhan-Baydrag ribbon continents during the Silurian-Devonian, associated with westward-subduction of the Mongol-Okhotsk Ocean and sequential growth of syn-convergent magmatic arcs. Back-arc basins opened during this period in the area of the western Paleoasian Ocean. The present-day shape of the CAOB in southern Mongolia was probably formed during Permian to Mesozoic anticlockwise rotation and folding of the Tuva-Mongol-Dzabkhan-Baydrag continental ribbons, combined with a strike-slip (transpressional) reactivation of ancient transform boundaries in the Paleoasian oceanic domain. All continental and oceanic crustal domains were reactivated and intensely deformed during this convergence in a style controlled by crustal rheology and a heterogeneous Permian magmatic-thermal input. The sequence of tectonic events is tested against published paleomagnetic data, paleogeographic reconstructions and tectonic models, leading to a revised model for the accretion of juvenile crust to a continental margin in the CAOB of southern Mongolia.