Medical career choices and Machiavellianism of 36 junior and 37 senior medical students at one private midwestern medical school were studied. Machiavellianism was measured by the Mach V Scale. Students choosing psychiatry did not score significantly higher on Machiavellianism than those choosing medicine, surgery, or other clinical medical specialties. This is contrary to previous research which indicated those medical students choosing psychiatry scored higher on Machiavellianism. There were no significant differences in Machiavellianism scores from two different age groups (20–30 yr. and 31–40 yr.). No significant differences were reported in Machiavellianism scores of 45 male and 29 female medical students or between junior and senior medical students.