A Process Design Kit (PDK) for gravure-printed Organic Thin-Film Transistor (OTFT) technology is presented in this paper. The transistor model developed in the PDK enables an accurate prediction of static, dynamic and noise performance of complex organic circuits. The developed Electronic Design Automation (EDA) tools exploit an adaptive strategy to improve the versatility of the PDK in relation to the advancements of the manufacturing process. The design and experimental characterization of a Charge Sensitive Amplifier is used to demonstrate the effectiveness of the PDK. The availability of a versatile and accurate Process Design Kit is expected to enable a reliable design process for complex circuits based on an organic printed technology.