Embedded devices in the Internet-of-Things require encryption functionalities to secure their communication. However, side-channel attacks and in particular differential power analysis (DPA) attacks pose a serious threat to cryptographic implementations. While state-of-the-art countermeasures like masking slow down the performance and can only prevent DPA up to a certain order, leakage-resilient schemes are designed to stay secure even in the presence of side-channel leakage. Although several leakage-resilient schemes have been proposed, there are no hardware implementations to demonstrate their practicality and performance on measurable silicon. In this work, we present an ASIC implementation of a multi-core System-on-Chip extended with a software-programmable accelerator for leakage-resilient cryptography. The accelerator is deeply embedded in the shared memory architecture of the many-core system, supports different configurations, contains a high-throughput implementation of the 2PRG primitive based on AES-128, offers two side-channel protected re-keying functions, and is the first fabricated design of the side-channel secure authenticated encryption scheme ISAP. The accelerator reaches a maximum throughput of 7.49Gbit/s and a best-case energy efficiency of 137 Gbit/s/W making this accelerator suitable for high-speed secure IoT applications.