This paper presents a design concept of new radio communication subsystem, intended for use on the PilsenCUBE nanosatellite. The hardware and software solution is based on previous experiences with the VZLUSAT-1 setup and operation. Our aim is to overcome weak points which were found, use modern powerful components actually available and build reliable radio for nanosatellite use. For better reliability, radiation tested components were used on critical place and complex system for diagnostics and fault protection was designed and implemented. The satellite radio communication protocol was also modified to comply with all requirements of nanosatellite operation. Satellite control data has to be secure, but significant part of experimen data need to be widely available to all ground segments on the World. This also improves the communication link capacity and reliability.