The state of international public health emergency, declared on January, 30th 2020 has seen an increase in frequency and intensity of health workers in the work place to support COVID-19 positive patients and indirectly their families. This has seen them come into direct contact with the lives and experiences of other people and with their own, both positive and negative,feeling compassion for those assisted and helplessness in the face of death. The observational study, conducted through the use of Kendall’s Self Report questionnaire ProQOL-Professional Quality of Life Scale (2009), version 5, consisting of 30 questions on a Likert scale (from 1 “never” to 5 “very often”), referable to three dimensions: Compassion Fatigue, Burnout and Compassion Satisfaction, allowed the 46 subjects involved to measure their inner resources, assessing the level of stress and emotions experienced. The representative sample of the Calabria region was selected randomly. Everyone was asked to fill in the online questionnaire, after dilling in a descriptive part related to demographic data such as age, sex, marital status, city of residence, profession, city where they work, years of work experience, length of the working week and the impact that the pandemic has had on their work. The results obtained from the research show a reduction in the quality of professional life perceived by health care professionals during the pandemic period.