
doi: 10.2307/3576928
pmid: 3659277
We have evaluated radiosensitivity parameters for cellular transformation from published experimental data on neoplastic transformations induced in C3H10T1/2 cells by BEVALAC ions. The measured RBE values are well reproduced by a track theory calculation using sets of m-target parameters with either m = 2 or m = 3, suggesting a quadratic or cubic extrapolation to low doses of gamma rays. Using track theory one is thus able to predict transformation frequencies in those cells after an arbitrary radiation field, under known or assumed conditions of exposure, in a manner shown earlier for cellular survival. Extension of these calculations to interpret cancer incidence in vivo is also discussed.
Ions, Cell Survival, Physics, X-Rays, Dose-Response Relationship, Radiation, Models, Theoretical, 530, Mice, Cell Transformation, Neoplastic, Energy Transfer, Metals, Animals, Particle Accelerators, Cell Line, Transformed
Ions, Cell Survival, Physics, X-Rays, Dose-Response Relationship, Radiation, Models, Theoretical, 530, Mice, Cell Transformation, Neoplastic, Energy Transfer, Metals, Animals, Particle Accelerators, Cell Line, Transformed
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