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Radiation Research
Article
Data sources: UnpayWall
Radiation Research
Article . 1973 . Peer-reviewed
Data sources: Crossref
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Carcinogenicity of Inhaled Plutonium-238 in the Rat

Authors: Sanders, C.L. Jr.;

Carcinogenicity of Inhaled Plutonium-238 in the Rat

Abstract

III). Only 1% of the initial alveolar lung burden remained in the lung at 1 year, decreasing to 0.3% by 600 days after exposure. The 23Pu body burden was 25% of initial alveolar burden at 1 year, decreasing to 12% by 1000 days after exposure; about half of the body burden was found in the skeleton at these times. The cumulative radiation doses to the lung at 2 years after exposure were 9 rads (I), 32 rads (II), and 375 rads (III). Unexposed controls exhibited a median survival tine of 825 days as compared to experimental survival times of 650 days (I), 675 days (II), and 550 days (III). The incidence of lung tumors in controls was 1.1% as compared to incidences in 23Pu-exposed rats of 6.6% (I), 20.0% (II), and 25.0% (III). The incidence of all tumors, other than mammary tumors, was 4.3% in unexposed controls, and in 238Pu-exposed rats, 26.7% (I),

Country
United States
Related Organizations
Keywords

Lung Neoplasms, Neoplasms, Radiation-Induced, Carcinogenesis, Radiation Doses, *Plutonium 238-- Biological Radiation Effects, Adrenal Gland Neoplasms, *Neoplasms-- Radioinduction, Adenocarcinoma, Nesdps Office Of Nuclear Energy Space And Defense Power Systems, Intestinal Neoplasms, *Lungs-- Radionuclide Kinetics, Radioactive Aerosols, Plutonium Oxides, Animals, Retention Radioinduction Nesdps Office Of Nuclear Energy Space And Defense Power Systems, Ovarian Neoplasms, Osteosarcoma, Lymphoma, Non-Hodgkin, Mammary Neoplasms, Experimental, Neoplasms, Experimental, Adenocarcinoma, Bronchiolo-Alveolar, Kidney Neoplasms, Plutonium, Rats, Pancreatic Neoplasms, Dose-Response Relationships, Inhalation, Leukemia, Myeloid, Abdominal Neoplasms, N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals, Carcinoma, Squamous Cell, Female, *Skeleton-- Radionuclide Kinetics, Adenofibroma

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
35
Average
Top 10%
Top 10%
bronze