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Biometrics
Article
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zbMATH Open
Article
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Biometrics
Article . 1995 . Peer-reviewed
Data sources: Crossref
Biometrics
Article . 1995
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Semi-Parametric Estimation in Failure Time Mixture Models

Semi-parametric estimation in failure time mixture models
Authors: Jeremy M. G. Taylor;

Semi-Parametric Estimation in Failure Time Mixture Models

Abstract

A mixture model is an attractive approach for analyzing failure time data in which there are thought to be two groups of subjects, those who could eventually develop the endpoint and those who could not develop the endpoint. The proposed model is a semi-parametric generalization of the mixture model of Farewell (1982). A logistic regression model is proposed for the incidence part of the model, and a Kaplan-Meier type approach is used to estimate the latency part of the model. The estimator arises naturally out of the EM algorithm approach for fitting failure time mixture models as described by Larson and Dinse (1985). The procedure is applied to some experimental data from radiation biology and is evaluated in a Monte Carlo simulation study. The simulation study suggests the semi-parametric procedure is almost as efficient as the correct fully parametric procedure for estimating the regression coefficient in the incidence, but less efficient for estimating the latency distribution.

Country
United States
Related Organizations
Keywords

Biometry, Guinea Pigs, radiation therapy, Spinal Cord Diseases, Applications of statistics to biology and medical sciences; meta analysis, Animals, Humans, Paralysis, Treatment Failure, EM algorithm, latency, Probability, Proportional Hazards Models, Models, Statistical, Radiotherapy, cure model, Kaplan-Meier estimator, logistic regression, Incidence, Dose-Response Relationship, Radiation, Survival Rate, Regression Analysis, long term incidence, Mathematics

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    188
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
188
Top 1%
Top 1%
Top 10%
Green
bronze