Mantel-Haenszel-Type Tests for Testing Equivalence or More Than Equivalence in Comparative Clinical Trials

This paper proposes Mantel-Haenszel-type statistics for testing whether a new treatment is at least as effective as the standard treatment in comparative binomial trials. The null hypotheses considered are of a specified nonzero difference and of a ratio not equal to unity. It is shown that we may also use these tests for testing the equivalence of two treatments.

Related Organizations

Kyushu University
Japan

Keywords

Biometry, Models, Statistical, Humans, Controlled Clinical Trials as Topic, Applications of statistics to biology and medical sciences; meta analysis

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