Pathogenicity, Attenuation, and Immunogenicity of Infectious Bursal Disease Virus

An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.

Related Organizations

Ohio Agricultural Research and Development Center
United States
The Ohio State University
United States

Keywords

Viral Vaccines, Birnaviridae Infections, Vaccines, Attenuated, Infectious bursal disease virus, Bursa of Fabricius, Neutralization Tests, Animals, Chickens, Poultry Diseases

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