A 2-year-old female ostrich had become gradually emaciated over a 4-month period and subsequently died. Gross necropsy revealed a granulomatous mass filling the right nasal passageways. Microscopically, the mass contained numerous thin, regular-diameter, septate, branching fungal hyphae consistent with Aspergillus sp. and foreign plant material. This appears to be the first report of a mycotic granuloma limited to the nasal cavities of an ostrich or any other ratite species.