The Gut Resistome is Highly Dynamic During the First Months of Life
Copyright policy )The Gut Resistome is Highly Dynamic During the First Months of Life
We investigated the longitudinal development of several antibiotic resistance genes (ARGs) of the infant gut resistome during the first months after birth.Fecal samples from 120 infants collected at the ages of 5, 13 and 31 weeks were analyzed and subjected to qPCR for the detection of several ARGs.The prevalence of ARGs significantly increased for ermB, tetM and tetQ, while it decreased for aac(6')-aph(2'). Birth mode and breastfeeding significantly affected tetQ prevalence. Correlations to bacterial taxa suggest that fluctuations in some ARGs are (partly) attributed to shifts in bacteroides colonization rates.Acquisition of ARGs in the gut microbiota occurs shortly after birth and resistome composition fluctuates over the course of several months, reflecting changes in microbial community structure.
- Humboldt-Universität zu Berlin Germany
- Maastricht University Medical Centre Netherlands
- Charité - University Medicine Berlin Germany
- Maastricht University Netherlands
- University Medical Center United States
Time Factors, gut microbiota, Bacteria, breastfeeding, resistomes, Infant, Newborn, microbiome, Real-Time Polymerase Chain Reaction, infant, metagenome, Gastrointestinal Tract, Feces, pediatric, bacteroides, Genes, Bacterial, Drug Resistance, Bacterial, Humans, Longitudinal Studies, antibiotic resistance gene, birth mode
Time Factors, gut microbiota, Bacteria, breastfeeding, resistomes, Infant, Newborn, microbiome, Real-Time Polymerase Chain Reaction, infant, metagenome, Gastrointestinal Tract, Feces, pediatric, bacteroides, Genes, Bacterial, Drug Resistance, Bacterial, Humans, Longitudinal Studies, antibiotic resistance gene, birth mode
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!